Did you already check out the latest Keybinding Cards of the new VS 2010? If not, you can find them here:
They are available for C#, C++, VB, and for the newly added F#.
Here are my two of my favourite new keybindings:
1. CTRL + COMMA (,) (NavigateTo window)
Cross-solution searching of matching elements of all types (be it file names, source code content, etc.). It’s a really fast searching mechanism. Further information about the NavigateTo feature can also be found in my previous post “Visual Studio 2010: New Features Part 1: UI”.
2. CTRL + SHIFT + PERIOD (.) and CTRL + SHIFT + COMMA (,)
Zoom in/out the source code editor, respectively. Very handy when it comes to presentations. Remember the old days where you had to increase/decrease the font size by going to the Tools menu (while your audience had to wait for it)? Those days are gone!